The Amiloride Derivative Phenamil Attenuates Pulmonary Vascular Remodeling by Activating NFAT and the Bone Morphogenetic Protein Signaling Pathway

Pulmonary artery hypertension (PAH) is characterized by elevated pulmonary artery resistance and increased medial thickness due to deregulation of vascular remodeling. Inactivating mutations of the BMPRII gene, which encodes a receptor for bone morphogenetic proteins (BMPs), are identified in ∼60% o...

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Main Authors: Chan, Mun Chun, Weisman, Alexandra S., Kang, Hara, Nguyen, Peter H., Hickman, Tyler, Mecker, Samantha V., Hill, Nicholas S., Lagna, Giorgio, Hata, Akiko
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2011
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028626/
https://ncbi.nlm.nih.gov/pubmed/21135135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00884-10
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