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Early Recruitment of AU-Rich Element-Containing mRNAs Determines Their Cytosolic Fate during Iron Deficiency

The yeast Cth2 protein is a CX(8)CX(5)CX(3)H tandem zinc finger protein that binds AU-rich element (ARE)-containing transcripts to enhance their decay in response to iron (Fe) deficiency. Mammalian members of this family of proteins are known to undergo nucleocytoplasmic shuttling, but little is kno...

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Autori principali: Vergara, Sandra V., Puig, Sergi, Thiele, Dennis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028617/
https://ncbi.nlm.nih.gov/pubmed/21135132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00754-10
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