Molecular changes in brain aging and Alzheimer’s disease are mirrored in experimentally silenced cortical neuron networks

Activity-dependent modulation of neuronal gene expression promotes neuronal survival and plasticity, and neuronal network activity is perturbed in aging and Alzheimer’s disease (AD). Here we show that cerebral cortical neurons respond to chronic suppression of excitability by downregulating the expr...

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Hauptverfasser: Gleichmann, Marc, Zhang, Yongqing, Wood, William H., Becker, Kevin G., Mughal, Mohamed R., Pazin, Michael J., van Praag, Henriette, Kobilo, Tali, Zonderman, Alan B., Troncoso, Juan C., Markesbery, William R., Mattson, Mark P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027841/
https://ncbi.nlm.nih.gov/pubmed/20947216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.08.012
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