Molecular changes in brain aging and Alzheimer’s disease are mirrored in experimentally silenced cortical neuron networks

Activity-dependent modulation of neuronal gene expression promotes neuronal survival and plasticity, and neuronal network activity is perturbed in aging and Alzheimer’s disease (AD). Here we show that cerebral cortical neurons respond to chronic suppression of excitability by downregulating the expr...

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Detalhes bibliográficos
Main Authors: Gleichmann, Marc, Zhang, Yongqing, Wood, William H., Becker, Kevin G., Mughal, Mohamed R., Pazin, Michael J., van Praag, Henriette, Kobilo, Tali, Zonderman, Alan B., Troncoso, Juan C., Markesbery, William R., Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027841/
https://ncbi.nlm.nih.gov/pubmed/20947216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.08.012
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