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Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex

BACKGROUND: Frataxin, the mitochondrial protein deficient in Friedreich ataxia, a rare autosomal recessive neurodegenerative disorder, is thought to be involved in multiple iron-dependent mitochondrial pathways. In particular, frataxin plays an important role in the formation of iron-sulfur (Fe-S) c...

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Main Authors: Schmucker, Stéphane, Martelli, Alain, Colin, Florent, Page, Adeline, Wattenhofer-Donzé, Marie, Reutenauer, Laurence, Puccio, Hélène
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027643/
https://ncbi.nlm.nih.gov/pubmed/21298097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016199
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