Abortive HIV Infection Mediates CD4 T-Cell Depletion and Inflammation in Human Lymphoid Tissue

The mechanism by which CD4 T-cells are depleted in HIV-infected hosts remains poorly understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced cytopathic response following HIV infection. Strikingly, >95% of these dying cells are not productively infected but instea...

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Hlavní autoři: Doitsh, Gilad, Cavrois, Marielle, Lassen, Kara G., Zepeda, Orlando, Yang, Zhiyuan, Santiago, Mario L., Hebbeler, Andrew M., Greene, Warner C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026834/
https://ncbi.nlm.nih.gov/pubmed/21111238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.001
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