β-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

β-Elemene is an active component of the herb medicine Curcuma Wenyujin with reported antitumor activity. To improve its antitumor ability, five novel piperazine derivatives of β-elemene, 13-(3-methyl-1-piperazinyl)-β-elemene (DX1), 13-(cis-3,5-dimethyl-1-piperazinyl)-β-elemene (DX2), 13-(4-ethyl-1-p...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yu, Zhiying, Wang, Rui, Xu, Liying, Xie, Siwei, Dong, Jinhua, Jing, Yongkui
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026787/
https://ncbi.nlm.nih.gov/pubmed/21283566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015843
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