Knockouts of SOD1 and GPX1 Exert Different Impacts on Murine Islet Function and Pancreatic Integrity

Metabolic subtlety and clinical relevance of different forms of reactive oxygen species in diabetes remain unclear. Using single knockout of Cu,Zn-superoxide dismutase (SOD1(-/-)) or Se-glutathione peroxidase-1 (GPX1(-/-)) and their double-knockout (DKO) mouse models, we determined if elevating endo...

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Detalhes bibliográficos
Main Authors: Wang, Xiaodan, Vatamaniuk, Marko Z., Roneker, Carol A., Pepper, Matthew P., Hu, Liangbiao G., Simmons, Rebecca A., Lei, Xin Gen
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Forum Original Research Communications Mitochondria and Diabetes (C. Leloup, Ed.)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026657/
https://ncbi.nlm.nih.gov/pubmed/20586612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3302
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