Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets

Our group previously demonstrated that overexpression of selenium-dependent glutathione peroxidase-1 (GPX1) in mice (OE) led to escalated glucose-stimulated insulin secretion and hyperinsulinemia. Because we found a strong correlation of this phenotype with a diminished expression of regenerating is...

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Gepubliceerd in:Free Radic Biol Med
Hoofdauteurs: Yun, Jun-Won, Zhao, Zeping, Yan, Xi, Vatamaniuk, Marko Z., Lei, Xin Gen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588445/
https://ncbi.nlm.nih.gov/pubmed/30703484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.01.024
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