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Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity
Mdm2 is an E3 ubiquitin ligase that targets p53 for degradation. p53(515C) (encoding p53R172P) is a hypomorphic allele of p53 that rescues the embryonic lethality of Mdm2(−/−) mice. Mdm2(−/−) p53(515C/515C) mice, however, die by postnatal day 13 due to hematopoietic failure. Hematopoietic stem cells...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026610/ https://ncbi.nlm.nih.gov/pubmed/21040902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.09.013 |
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