Effect of immunoglobulin G (IgG) interchain disulfide bond cleavage on efficacy of intravenous immunoglobulin for immune thrombocytopenic purpura (ITP)

Intravenous immunoglobulin (IVIG) has been used widely to treat immune thrombocytopenic purpura (ITP), but the mechanisms of its action remain unclear. We investigated the affinity for Fcγ receptors (FcγRs) and the thrombocytopenia-ameliorating effect of S-sulfonated gammaglobulin (SGG) and S-alkyla...

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Autors principals: Machino, Y, Ohta, H, Suzuki, E, Higurashi, S, Tezuka, T, Nagashima, H, Kohroki, J, Masuho, Y
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2010
Matèries:
Translational Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026545/
https://ncbi.nlm.nih.gov/pubmed/21029072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04255.x
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