Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice

This study examined the role of forebrain N-methyl-D-aspartate receptors (NMDA-Rs) in the promnesiant effects of natural (+) pregnenolone sulfate (PREGS) and its synthetic (−) enantiomer ent-PREGS in young adult mice. Using the two-trial arm discrimination task in a Y-maze, PREGS and ent-PREGS admin...

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Autores principales: Petit, Géraldine H., Tobin, Christine, Krishnan, Kathiresan, Moricard, Yves, Covey, Douglas F., Rondi-Reig, Laure, Akwa, Yvette
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026085/
https://ncbi.nlm.nih.gov/pubmed/21036556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euroneuro.2010.09.010
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