Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression

BACKGROUND: SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elev...

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Главные авторы: Javelaud, Delphine, van Kempen, Leon, Alexaki, Vasileia I, Le Scolan, Erwan, Luo, Kunxin, Mauviel, Alain
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2011
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025974/
https://ncbi.nlm.nih.gov/pubmed/21211030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-2
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