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Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca(2+ )channels

BACKGROUND: N-type Ca(2+ )channels (Ca(v)2.2) play an important role in the transmission of pain signals to the central nervous system. ω-Conotoxin (CTx)-MVIIA, also called ziconotide (Prialt(®)), effectively alleviates pain, without causing addiction, by blocking the pores of these channels. Unfort...

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Detalhes bibliográficos
Main Authors: Lee, Seungkyu, Kim, Yoonji, Back, Seung Keun, Choi, Hee-Woo, Lee, Ju Yeon, Jung, Hyun Ho, Ryu, Jae Ha, Suh, Hong-Won, Na, Heung Sik, Kim, Hyun Jeong, Rhim, Hyewhon, Kim, Jae Il
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025903/
https://ncbi.nlm.nih.gov/pubmed/21172037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-97
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