Oestrogens ameliorate mitochondrial dysfunction in Leber’s hereditary optic neuropathy

Leber’s hereditary optic neuropathy, the most frequent mitochondrial disease due to mitochondrial DNA point mutations in complex I, is characterized by the selective degeneration of retinal ganglion cells, leading to optic atrophy and loss of central vision prevalently in young males. The current st...

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Detalhes bibliográficos
Main Authors: Giordano, Carla, Montopoli, Monica, Perli, Elena, Orlandi, Maurizia, Fantin, Marianna, Ross-Cisneros, Fred N., Caparrotta, Laura, Martinuzzi, Andrea, Ragazzi, Eugenio, Ghelli, Anna, Sadun, Alfredo A., d’Amati, Giulia, Carelli, Valerio
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025718/
https://ncbi.nlm.nih.gov/pubmed/20943885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awq276
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