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Dissecting endonuclease and exonuclease activities in endonuclease V from Thermotoga maritima

Endonuclease V is an enzyme that initiates a conserved DNA repair pathway by making an endonucleolytic incision at the 3′-side 1 nt from a deaminated base lesion. DNA cleavage analysis using mutants defective in DNA binding and Mn(2+) as a metal cofactor reveals a novel 3′-exonuclease activity in en...

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Hlavní autoři: Mi, Rongjuan, Abole, Anne K., Cao, Weiguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025561/
https://ncbi.nlm.nih.gov/pubmed/20852258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq791
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