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Chromatin Remodeling at the Topoisomerase II-beta Promoter is Associated with Enhanced Sensitivity to Etoposide in Human Neuroblastoma Cell Lines

Etoposide, an inhibitor of topoisomerase II, promotes DNA damage and apoptosis of cancer cells and is a component of standard therapy for neuroblastoma. Resistance to etoposide has been observed in neural tumor cells expressing lower levels of topoisomerase II. In the present study, we have examined...

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Autori principali: Das, Chandra M., Zage, Peter E., Taylor, Pete, Aguilera, Dolly, Wolff, Johannes E.A., Lee, Dean, Gopalakrishnan, Vidya
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025305/
https://ncbi.nlm.nih.gov/pubmed/20886683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.05.010
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