Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B

New classes of drugs are needed to combat hepatitis C virus (HCV), an important worldwide cause of liver disease. We describe an activity of a key domain, an amphipathic helix we termed 4BAH2, within a specific HCV nonstructural protein, NS4B. In addition to its proposed role in viral replication, w...

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Hlavní autoři: Cho, Nam-Joon, Dvory-Sobol, Hadas, Lee, Choongho, Cho, Sang-Joon, Bryson, Paul, Masek, Marilyn, Elazar, Menashe, Frank, Curtis W., Glenn, Jeffrey S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025298/
https://ncbi.nlm.nih.gov/pubmed/20371471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000331
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