Multiple Endocrine Neoplasia Type 2B with a RET Proto-Oncogene A883F Mutation Displays a More Indolent Form of Medullary Thyroid Carcinoma Compared with a RET M918T Mutation

BACKGROUND: Most cases of multiple endocrine neoplasia type 2B (MEN-2B) are attributable to a germline methionine to threonine mutation at codon 918 (M918T) of the RET proto-oncogene; very few cases of a germline alanine to phenylalanine mutation at codon 883 (A883F) are reported without a clear des...

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Main Authors: Jasim, Sina, Ying, Anita K., Waguespack, Steven G., Rich, Thereasa A., Grubbs, Elizabeth G., Jimenez, Camilo, Hu, Mimi I., Cote, Gilbert, Habra, Mouhammed Amir
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2011
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025175/
https://ncbi.nlm.nih.gov/pubmed/21186952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2010.0328
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