Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P(33-42)

BACKGROUND: Fibrolytic and profibrotic activities of the matrix metalloproteinases (MMPs)-2 and -9 play a central role in liver fibrosis. Since binding to the extracellular matrix influences the activity of both gelatinases, here the role of fibrillar collagens as the most abundant matrix components...

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Detalhes bibliográficos
Main Authors: Ruehl, Martin, Muche, Marion, Freise, Christian, Erben, Ulrike, Neumann, Ulf, Schuppan, Detlef, Popov, Yury, Dieterich, Walburga, Zeitz, Martin, Farndale, Richard W, Somasundaram, Rajan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024946/
https://ncbi.nlm.nih.gov/pubmed/21211003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-1536-4-1
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