Phase II Trial of Depsipeptide (NSC-630176) in Previously Treated Colorectal Cancer Patients with Advanced Disease: A Southwest Oncology Group Study (S0336)

INTRODUCTION: Patients with metastatic colorectal cancer who progress on standard chemotherapy have limited treatment options. New and effective drugs are needed for these patients. Depsipeptide is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to m...

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Detalhes bibliográficos
Main Authors: Whitehead, Robert P., Rankin, Cathryn, Hoff, Paulo M.G., Gold, Philip J., Billingsley, Kevin G., Chapman, Robert A., Wong, Lucas, Ward, John H., Blanke, Charles D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024913/
https://ncbi.nlm.nih.gov/pubmed/18941712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-008-9190-8
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