Activation State of α4β1 Integrin on Sickle Red Blood Cells Is Linked to the Duffy Antigen Receptor for Chemokines (DARC) Expression

In sickle cell anemia, reticulocytes express enhanced levels of α4β1 integrin that interact mainly with vascular cell adhesion molecule-1 and fibronectin, promoting vaso-occlusion. These interactions are known to be highly sensitive to the inflammatory chemokine IL-8. The Duffy antigen receptor for...

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Main Authors: Durpès, Marie-Claude, Hardy-Dessources, Marie-Dominique, El Nemer, Wassim, Picot, Julien, Lemonne, Nathalie, Elion, Jacques, Decastel, Monique
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024799/
https://ncbi.nlm.nih.gov/pubmed/21088296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173229
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