HIV and HCV Cooperatively Promote Hepatic Fibrogenesis via Induction of Reactive Oxygen Species and NFκB

HIV/HCV coinfection leads to accelerated hepatic fibrosis progression, with higher rates of cirrhosis, liver failure, and liver death than does HCV mono-infection. However, the profibrogenic role of HIV on hepatocytes and hepatic stellate cells (HSC) has not been fully clarified. We hypothesized tha...

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Autores principales: Lin, Wenyu, Wu, Guoyang, Li, Shaoyong, Weinberg, Ethan M., Kumthip, Kattareeya, Peng, Lee F., Méndez-Navarro, Jorge, Chen, Wen-Chi, Jilg, Nikolaus, Zhao, Hong, Goto, Kaku, Zhang, Leiliang, Brockman, Mark A., Schuppan, Detlef, Chung, Raymond T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024762/
https://ncbi.nlm.nih.gov/pubmed/21098019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.168286
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