The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein

The amyloid precursor protein (APP) is cleaved by β- and γ-secretases to generate the β-amyloid (Aβ) peptides, which are present in large amounts in the amyloid plaques of Alzheimer disease (AD) patient brains. Non-amyloidogenic processing of APP by α-secretases leads to proteolytic cleavage within...

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Bibliographic Details
Main Authors: Delarasse, Cécile, Auger, Rodolphe, Gonnord, Pauline, Fontaine, Bertrand, Kanellopoulos, Jean M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024755/
https://ncbi.nlm.nih.gov/pubmed/21081501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200618
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