Ezrin/Radixin/Moesin Are Required for the Purinergic P2X7 Receptor (P2X7R)-dependent Processing of the Amyloid Precursor Protein

The amyloid precursor protein (APP) can be cleaved by α-secretases in neural cells to produce the soluble APP ectodomain (sAPPα), which is neuroprotective. We have shown previously that activation of the purinergic P2X7 receptor (P2X7R) triggers sAPPα shedding from neural cells. Here, we demonstrate...

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Библиографические подробности
Главные авторы: Darmellah, Amaria, Rayah, Amel, Auger, Rodolphe, Cuif, Marie-Hélène, Prigent, Magali, Arpin, Monique, Alcover, Andres, Delarasse, Cécile, Kanellopoulos, Jean M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464564/
https://ncbi.nlm.nih.gov/pubmed/22891241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400010
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