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Influence of ApoA-I Domain Structure on Macrophage Reverse Cholesterol Transport in Mice

OBJECTIVE: To determine the influence of apoA-I tertiary structure domain properties on the anti-atherogenic properties of the protein. Two chimeric hybrids with the N-terminal domains swapped (human-M apoA-I and mouse-H apoA-I) were expressed in apoA-I-null mice with adeno-associated virus (AAV) an...

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Autores principales: Alexander, Eric T., Vedhachalam, Charulatha, Sankaranarayanan, Sandhya, de la Llera-Moya, Margarita, Rothblat, George H., Rader, Daniel J., Phillips, Michael C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024460/
https://ncbi.nlm.nih.gov/pubmed/21071688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.216226
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