The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest anima...

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Detalhes bibliográficos
Main Authors: Loenarz, Christoph, Coleman, Mathew L, Boleininger, Anna, Schierwater, Bernd, Holland, Peter W H, Ratcliffe, Peter J, Schofield, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024122/
https://ncbi.nlm.nih.gov/pubmed/21109780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.170
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