Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice

The mitochondrial Hsp60 chaperonin plays an important role in sustaining cellular viability. Its dysfunction is related to inherited forms of the human diseases spastic paraplegia and hypomyelinating leukodystrophy. However, it is unknown whether the requirement for Hsp60 is neuron specific or wheth...

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Bibliographic Details
Main Authors: Christensen, Jane H., Nielsen, Marit N., Hansen, Jakob, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, West, Mark, Corydon, Thomas J., Gregersen, Niels, Bross, Peter
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2010
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024079/
https://ncbi.nlm.nih.gov/pubmed/20393889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-010-0194-x
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