Compensatory Changes in the Cytoplasmic Tail of gp41 Confer Resistance to Tetherin/BST-2 in a Pathogenic Nef-deleted SIV

Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that inhibits virus release from infected cells. Whereas HIV-1 Vpu and HIV-2 Env counteract human tetherin, most SIVs use Nef to antagonize the tetherin proteins of their non-human primate hosts. Here we show that compensator...

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Bibliographic Details
Main Authors: Serra-Moreno, Ruth, Jia, Bin, Breed, Matthew, Alvarez, Xavier, Evans, David T.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023977/
https://ncbi.nlm.nih.gov/pubmed/21238946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.12.005
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