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Keratin Hypersumoylation Alters Filament Dynamics and Is a Marker for Human Liver Disease and Keratin Mutation

Keratin polypeptide 8 (K8) associates noncovalently with its partners K18 and/or K19 to form the intermediate filament cytoskeleton of hepatocytes and other simple-type epithelial cells. Human K8, K18, and K19 variants predispose to liver disease, whereas site-specific keratin phosphorylation confer...

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Main Authors: Snider, Natasha T., Weerasinghe, Sujith V. W., Iñiguez-Lluhí, Jorge A., Herrmann, Harald, Omary, M. Bishr
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023522/
https://ncbi.nlm.nih.gov/pubmed/21062750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.171314
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