PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation

A subset of poly ADP-ribose polymerases (PARP) that also contain macro domains regulate transcription. One such macro PARP, PARP-14 alters interleukin 4 (IL-4) and Stat6-dependent transcription. Stat6, activated by IL-4 plays an important role in T helper cell immunity and B cell responses. Here we...

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Bibliographic Details
Main Authors: Mehrotra, Purvi, Riley, Jonathan P., Patel, Ravi, Li, Fang, Voss, Le'erin, Goenka, Shreevrat
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023471/
https://ncbi.nlm.nih.gov/pubmed/21081493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.157768
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