Defective trafficking and function of K(ATP) channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy

The ATP-sensitive potassium channel (K(ATP)) regulates insulin secretion in pancreatic β cells. Loss of functional K(ATP) channels because of mutations in either the SUR1 or Kir6.2 channel subunit causes persistent hyperinsulinemic hypoglycemia of infancy (PHHI). We investigated the molecular mechan...

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Bibliographic Details
Main Authors: Cartier, Etienne A., Conti, Lisa R., Vandenberg, Carol A., Shyng, Show-Ling
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC30234/
https://ncbi.nlm.nih.gov/pubmed/11226335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051499698
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