Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1

Reactive oxygen species (ROS) are important mediators of cellular signal transduction cascades such as proliferation, migration, and apoptosis. Chronic exposure of isolated β-cells to proinflammatory cytokines elevates intracellular oxidative stress leading to the demise of pancreatic β-cells culmin...

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Hlavní autoři: Subasinghe, Wasanthi, Syed, Ismail, Kowluru, Anjaneyulu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2011
Témata:
Call for Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023281/
https://ncbi.nlm.nih.gov/pubmed/20943855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00421.2010
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