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Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation

Elevated level of homocysteine (Hcy) induces chronic inflammation in vascular bed, including glomerulus, and promotes glomerulosclerosis. In this study we investigated in vitro mechanism of Hcy-mediated monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) inductio...

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Autors principals: Sen, Utpal, Givvimani, Srikanth, Abe, Oluwasegun A., Lederer, Eleanor D., Tyagi, Suresh C.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023186/
https://ncbi.nlm.nih.gov/pubmed/20943958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00143.2010
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