Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation

Elevated level of homocysteine (Hcy) induces chronic inflammation in vascular bed, including glomerulus, and promotes glomerulosclerosis. In this study we investigated in vitro mechanism of Hcy-mediated monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) inductio...

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Autori principali: Sen, Utpal, Givvimani, Srikanth, Abe, Oluwasegun A., Lederer, Eleanor D., Tyagi, Suresh C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
Soggetti:
Vascular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023186/
https://ncbi.nlm.nih.gov/pubmed/20943958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00143.2010
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