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Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation

Elevated level of homocysteine (Hcy) induces chronic inflammation in vascular bed, including glomerulus, and promotes glomerulosclerosis. In this study we investigated in vitro mechanism of Hcy-mediated monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) inductio...

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Detalhes bibliográficos
Main Authors: Sen, Utpal, Givvimani, Srikanth, Abe, Oluwasegun A., Lederer, Eleanor D., Tyagi, Suresh C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023186/
https://ncbi.nlm.nih.gov/pubmed/20943958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00143.2010
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