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Inhibition of Sonic Hedgehog and Notch Pathways Enhances Sensitivity of CD133(+) Glioma Stem Cells to Temozolomide Therapy

Malignant gliomas are currently treated with temozolomide (TMZ), but often exhibit resistance to this agent. CD133(+) cancer stem cells, a population believed to contribute to the tumor’s chemoresistance, bear the activation of Notch and Sonic hedgehog (SHH) pathways. In this study, we examined whet...

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Détails bibliographiques
Auteurs principaux: Ulasov, Ilya V, Nandi, Suvobroto, Dey, Mahua, Sonabend, Adam M, Lesniak, Maciej S
Format: Artigo
Langue:Inglês
Publié: ScholarOne 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022974/
https://ncbi.nlm.nih.gov/pubmed/20957337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2010.00062
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