An RNAi in silico approach to find an optimal shRNA cocktail against HIV-1

BACKGROUND: HIV-1 can be inhibited by RNA interference in vitro through the expression of short hairpin RNAs (shRNAs) that target conserved genome sequences. In silico shRNA design for HIV has lacked a detailed study of virus variability constituting a possible breaking point in a clinical setting....

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Autors principals: Méndez-Ortega, María C, Restrepo, Silvia, Rodríguez-R, Luis M, Pérez, Iván, Mendoza, Juan C, Martínez, Andrés P, Sierra, Roberto, Rey-Benito, Gloria J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022682/
https://ncbi.nlm.nih.gov/pubmed/21172023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-369
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