Preclinical evaluation of KIT/PDGFRA and mTOR inhibitors in gastrointestinal stromal tumors using small animal FDG PET

BACKGROUND: Primary and secondary drug resistance to imatinib and sunitinib in patients with gastrointestinal stromal tumors (GISTs) has led to a pressing need for new therapeutic strategies such as drug combinations. Most GISTs are caused by mutations in the KIT receptor, leading to upregulated KIT...

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Detalhes bibliográficos
Main Authors: Pantaleo, Maria Abbondanza, Nicoletti, Giordano, Nanni, Cristina, Gnocchi, Chiara, Landuzzi, Lorena, Quarta, Carmelo, Boschi, Stefano, Nannini, Margherita, Di Battista, Monica, Castellucci, Paolo, Fanti, Stefano, Lollini, Pier Luigi, Bellan, Elena, Castelli, Mauro, Rubello, Domenico, Biasco, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022678/
https://ncbi.nlm.nih.gov/pubmed/21192792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-29-173
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