Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma

BACKGROUND: Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or overexpression of the PDGF ligand, resulting in the activation of downstream kinases such as phosphatidylinositol 3-kinase (PI3K),...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pitter, Kenneth L., Galbán, Craig J., Galbán, Stefanie, Saeed-Tehrani, Omid, Li, Fei, Charles, Nikki, Bradbury, Michelle S., Becher, Oren J., Chenevert, Thomas L., Rehemtulla, Alnawaz, Ross, Brian D., Holland, Eric C., Hambardzumyan, Dolores
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022633/
https://ncbi.nlm.nih.gov/pubmed/21267448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014545
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados