The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian Hibernation

Abnormal phosphorylation and aggregation of tau protein are hallmarks of a variety of neurological disorders, including Alzheimer's disease (AD). Increased tau phosphorylation is assumed to represent an early event in pathogenesis and a pivotal aspect for aggregation and formation of neurofibri...

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Main Authors: Stieler, Jens T., Bullmann, Torsten, Kohl, Franziska, Tøien, Øivind, Brückner, Martina K., Härtig, Wolfgang, Barnes, Brian M., Arendt, Thomas
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022585/
https://ncbi.nlm.nih.gov/pubmed/21267079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014530
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