Action at a Distance: Lengthening Adhesion Bonds with Poly(ethylene glycol) Spacers Enhances Mechanically Stressed Affinity for Improved Vascular Targeting of Microparticles

Poly(ethylene glycol) (PEG) chains were used to decorate microparticles with long adhesion ligands to emulate the efficacy of selectin-mediated leukocyte homing mechanisms. Ligands for P-selectin, an endothelial cell inflammatory marker, were coupled to PEG spacers of two sizes (MW 3400 Da and 10000...

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Bibliographic Details
Main Authors: Ham, Anthony Sang Won, Klibanov, Alexander L., Lawrence, Michael B.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022502/
https://ncbi.nlm.nih.gov/pubmed/19621909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/la900966h
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