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Action at a Distance: Lengthening Adhesion Bonds with Poly(ethylene glycol) Spacers Enhances Mechanically Stressed Affinity for Improved Vascular Targeting of Microparticles

Poly(ethylene glycol) (PEG) chains were used to decorate microparticles with long adhesion ligands to emulate the efficacy of selectin-mediated leukocyte homing mechanisms. Ligands for P-selectin, an endothelial cell inflammatory marker, were coupled to PEG spacers of two sizes (MW 3400 Da and 10000...

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Sonraí Bibleagrafaíochta
Main Authors: Ham, Anthony Sang Won, Klibanov, Alexander L., Lawrence, Michael B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022502/
https://ncbi.nlm.nih.gov/pubmed/19621909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/la900966h
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