TNFα Cooperates with IFN-γ to Repress Bcl-xL Expression to Sensitize Metastatic Colon Carcinoma Cells to TRAIL-mediated Apoptosis

BACKGROUND: TNF-related apoptosis-inducing ligand (TRAIL) is an immune effector molecule that functions as a selective anti-tumor agent. However, tumor cells, especially metastatic tumor cells often exhibit a TRAIL-resistant phenotype, which is currently a major impediment in TRAIL therapy. The aim...

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Detalhes bibliográficos
Main Authors: Liu, Feiyan, Hu, Xiaolin, Zimmerman, Mary, Waller, Jennifer L., Wu, Ping, Hayes-Jordan, Andrea, Lev, Dina, Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022032/
https://ncbi.nlm.nih.gov/pubmed/21264227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016241
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