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Induction of anti-glioma NK cell response following multiple low-dose intracerebral CpG therapy

PURPOSE: Stimulation of toll-like receptor-9 (TLR9) by CpG oligodeoxynucleotides (CpG-ODN) has been shown to counteract the immunosuppressive microenvironment and to inhibit tumor growth in glioma models. These studies, however, have used high doses of CpG-ODN which can induce toxicity in a clinical...

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Main Authors: Alizadeh, Darya, Zhang, Leying, Brown, Christine E., Farrukh, Omar, Jensen, Michael C., Badie, Behnam
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022005/
https://ncbi.nlm.nih.gov/pubmed/20570924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3087
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