A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

Here, we have investigated mitochondrial biology and energy metabolism in human embryonic stem cells (hESCs) and hESC-derived neural stem cells (NSCs). Although stem cells collectively in vivo might be expected to rely primarily on anaerobic glycolysis for ATP supply, to minimise production of react...

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Main Authors: Birket, Matthew J., Orr, Adam L., Gerencser, Akos A., Madden, David T., Vitelli, Cathy, Swistowski, Andrzej, Brand, Martin D., Zeng, Xianmin
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2011
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021997/
https://ncbi.nlm.nih.gov/pubmed/21242311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.072272
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