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Tryptophan–Kynurenine Metabolism as a Common Mediator of Genetic and Environmental Impacts in Major Depressive Disorder: The Serotonin Hypothesis Revisited 40 Years Later
The original 1969 Lancet paper proposed, “in depression the activity of liver tryptophan-pyrrolase is stimulated by raised blood corticosteroids levels, and metabolism of tryptophan is shunted away from serotonin production, and towards kynurenine production.” Discovery of neurotropic activity of ky...
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| Format: | Artigo |
| Sprache: | Inglês |
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2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021918/ https://ncbi.nlm.nih.gov/pubmed/20686200 |
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