Loss Of Klotho During Melanoma Progression Leads To Increased Filamin Cleavage, Increased Wnt5A Expression and Enhanced Melanoma Cell Motility

We have previously shown that Wnt5A-mediated signaling can promote melanoma metastasis. It has been shown that Wnt signaling is antagonized by the protein Klotho, which has been implicated in aging. We show here that in melanoma cells, expressions of Wnt5A and Klotho are inversely correlated. In the...

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Main Authors: Camilli, Tura C., Xu, Mai, O'Connell, Michael P., Chien, Bonnie, Frank, Brittany P., Subaran, Sarah, Indig, Fred E., Morin, Patrice J., Hewitt, Stephen M., Weeraratna, Ashani T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021583/
https://ncbi.nlm.nih.gov/pubmed/20955350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2010.00792.x
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