Steroids Up-Regulate p66Shc Longevity Protein in Growth Regulation by Inhibiting Its Ubiquitination

BACKGROUND: p66Shc, an isoform of Shc adaptor proteins, mediates diverse signals, including cellular stress and mouse longevity. p66Shc protein level is elevated in several carcinomas and steroid-treated human cancer cells. Several lines of evidence indicate that p66Shc plays a critical role in ster...

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Detalhes bibliográficos
Main Authors: Kumar, Santosh, Kumar, Satyendra, Rajendran, Mythilypriya, Alam, Syed Mahfuzul, Lin, Fen-Fen, Cheng, Pi-Wan, Lin, Ming-Fong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021521/
https://ncbi.nlm.nih.gov/pubmed/21264241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015942
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