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Reduced effects of BAY K 8644 on L-type Ca(2+) current in failing human cardiac myocytes are related to abnormal adrenergic regulation
Abnormal L-type Ca(2+) channel (LTCC, also named Cav1.2) density and regulation are important contributors to depressed contractility in failing hearts. The LTCC agonist BAY K 8644 (BAY K) has reduced inotropic effects on failing myocardium. We hypothesized that BAY K effects on the LTCC current (I(...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021380/ https://ncbi.nlm.nih.gov/pubmed/18359894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01335.2007 |
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