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Reduced effects of BAY K 8644 on L-type Ca(2+) current in failing human cardiac myocytes are related to abnormal adrenergic regulation

Abnormal L-type Ca(2+) channel (LTCC, also named Cav1.2) density and regulation are important contributors to depressed contractility in failing hearts. The LTCC agonist BAY K 8644 (BAY K) has reduced inotropic effects on failing myocardium. We hypothesized that BAY K effects on the LTCC current (I(...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Chen, Xiongwen, Zhang, Xiaoying, Harris, David M., Piacentino, Valentino, Berretta, Remus M., Margulies, Kenneth B., Houser, Steven R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2008
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021380/
https://ncbi.nlm.nih.gov/pubmed/18359894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01335.2007
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